Hepcidin Mimetic Mechanism: Scientific Rationale in Polycythemia Vera | Targeted Oncology - Immunotherapy, Biomarkers, and Cancer Pathways

Testosterone regulates iron behavior in the body. Michael McEvoy @michaelemcevoy details how chronic inflammation distorts iron metabolism, leading to anemia of inflammation and immune system imbalance. Current findings suggest anemia of inflammation reflects iron sequestration within macrophages and liver, driven by immune activation and elevated hepcidin; iron supports mitochondrial energy production through iron sulfur complexes, serving both host metabolism and microbial competition; and tes