Nature

Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG

In central neurons, the second messenger cGMP is believed to induce long-term changes in efficacy at glutamatergic synapses through activation of protein kinase G (PKG). Stimulating nitric oxide ...
JD Supra

FDA’s New Guidance on Data Integrity and Compliance with GMPs and Potential Product Liability Considerations

The Food and Drug Administration recently released draft guidance for the industry entitled “Data Integrity and Compliance with CGMP [Current Good Manufacturing Practices].” While the draft is not ...
Nature

Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons

In various species, peripheral injury produces long–lasting sensitization of central and peripheral neurons representing the affected area 1,2. In Aplysia, memory–like traces (lasting days or weeks) ...
Business Insider

ABL, Inc. Awarded Multiple-Award IDIQ Contract to Provide cGMP Manufacturing Services in support of the PREVENT Cancer Preclinical Cancer Prevention Program

ROCKVILLE, Md., Oct. 8, 2019 /PRNewswire/ -- Advanced BioScience Laboratories, Inc. (ABL), a global contract development and manufacturing organization for biotherapeutics and vaccines, announced ...