Strictly-speaking modern x86 computers running Windows should be compatible with any software written for the very first MS-DOS PCs starting with the original IBM PC and its clones. In practice, it's ...

If you're trying to get this stuff going to play games, as opposed to simulate owning an old PC, just use DOSBox-X. You still have to mess with text config files, but it's got both MT32 and General ...

vDos is a DOS emulator designed to run old DOS programs on modern Windows operating systems, particularly useful for 64-bit versions where the built-in NTVDM (NT Virtual DOS Machine) is not available.