Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men. While early-stage disease can be effectively managed, advanced forms-particularly metastatic ...
Image Caption: The role of SOX2 in lineage conversion from CRPC to NEPC. SOX2’s role in treatment resistance is particularly significant. It supports resistance to chemotherapy by inducing a ...
Researchers have found that heterozygous loss of the methyl-CpG binding protein Zbtb38 downregulated the expression of the transcription factors Nanog and Sox2, as well as genes involved in epiblast ...
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