When replication forks collapse, Rad3 phosphorylates the checkpoint-clamp protein Rad9 in a manner that depends on Thr 225, a residue within the PCNA-like domain. The physiological function of Thr 225 ...
New research provides mechanistic insight into how DNA is monitored and repaired if damage occurs. The results may eventually help to improve the treatment of certain types of cancer, as the DNA ...
The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...
Nucleases can cleave stalled forks, causing double-strand breaks (DSBs) to form and activate ataxia-telangiectasia mutated (ATM). The rate at which DSBs form at stalled forks is greatly increased in ...
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