The kidney's proximal tubule reabsorbs water, glucose, ions and other small molecules from the urine and thus maintains the ...

aProximate TM is an advanced in vitro model of kidney proximal tubule cells (PTCs) that closely mimics physiological conditions. Derived from fresh human kidney tissue, aProximate TM PTCs are cultured ...

While new drug molecules are typically tested in vivo in two preclinical species to better understand how they are transported and eliminated by the kidney and assess the risk of renal toxicity in ...

A team developed a human iPS cell-derived kidney organoid-based proximal tubule-on-chip -- OPTECs-on-Chip -- that mimics in vivo renal physiology more closely than ever before. This model exhibits ...

Kyoto, Japan -- Animal experimentation may not be a thing of the past just yet, but work on human iPS cell technology may someday grant emancipation for lab mice and other species. Renal proximal ...

“You’re on a chemotherapeutic and your oncologist may say that your dosage is X, while a nephrologist is telling you that the proximal tubules in your kidneys can’t handle it. You’re harming them.” ...

In the lab, it’s easier to grow simple balls of cells than complex asymmetrical structures with two distinct ends—like the one million filtering units, or nephrons, that make up a human kidney. But ...

Scientists have discovered a previously unknown 'housekeeping' process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy.

Autosomal dominant polycystic kidney disease (ADPKD) is a frequently occurring inherited condition characterised by the formation of multiple cysts and considerable enlargement of both kidneys. The ...

The kidneys contain millions of microscopic blood vessels known as peritubular capillaries. These vessels recapture helpful nutrients like glucose and minerals and return them to your bloodstream for ...