The hepatocyte is a main contributor to liver functions, including in metabolic homeostasis, synthesis, storage, distribution, and detoxification of xenobiotic compounds. Hepatocyte polyploidization ...

This is a preview. Log in through your library . Abstract Somatic polyploidization is recognized as a means to increase gene expression levels in highly active metabolic cells. The most common ...

This is a preview. Log in through your library . Abstract Allopolyploidization, resulting in divergent genomes in the same cell, is believed to trigger a “genome shock”, leading to broad genetic and ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes. Their ...

Polyploidization, the combination and duplication of genomes, is a major driver of plant evolution and diversification. Yet this process causes "genome shock," leading to rapid activation of ...

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies. Polyploidy often occurs in human diseases and cancers, and its ...