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New review reveals complex polygenic architecture underlying common epilepsies
An insightful mini-review published in Genomic Psychiatry synthesizes the rapidly expanding landscape of molecular genetic research on common epilepsies, assembling evidence from genome-wide ...
A new synthesis finds that common epilepsies are driven by thousands of tiny-effect genetic variants, most still ...
A new study links telomere length and polygenic risk scores to IPF development, highlighting genetic drivers beyond rare variants. The role of polygenic risk scores in patients with idiopathic ...
Polygenic risk scores (PRS) combined with clinical factors improve POAG risk prediction, aiding in identifying high-risk patients. The study used OHTS data, showing low polygenic risk correlates with ...
Atrial fibrillation (AF) is a common arrhythmia associated with increased risk of stroke, heart failure and mortality. Advances in genomic research have revealed a complex genetic architecture ...
Genetic variants associated with mental disorders do not have a significant influence on methylphenidate response in ADHD cohorts.
The optimism is not unfounded. In specific, well-defined clinical scenarios, polygenic scores are beginning to demonstrate some tangible utility. For cardiovascular disease, MI-GENES, a 10-year follow ...
Cost-utility studies provide critical information for the costs and benefits of using any new test, typically building on existing public health and screening programmes, within a defined population.
Survey reveals nearly three-quarters of U.S. adults support using emerging technology to screen embryos during IVF for risk of developing certain health conditions or traits that arise from more than ...
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