The primary rationale for middle-down proteomics is the need for high-confidence proteoform analysis that is also scalable. A proteoform is defined by its full complement of modifications and sequence ...

Effective protein characterization depends on the precise isolation and fragmentation of peptide ions within the mass spectrometer, typically coupled with liquid chromatography (LC-MS/MS). In a ...

Tandem mass spectrometry is a powerful tool in proteomics. By ionizing peptides and then fragmenting those ions into smaller product ions, researchers can determine the biomolecules’ amino acid ...