Proper embryonic development of the fruit fly Drosophila melanogaster is governed by patterns of protein activity bequeathed to the fertilized egg by its mother. While the embryo is still a single ...

Pasca Lab specializes in growing three-dimensional organoid models from reprogrammed stem cells, which capture molecular changes during fetal brain-like development. Because the human brain cannot be ...

Caroline Block, MD: With regard to the development of clinical pathways, we started doing them at Dana-Farber [Cancer Institute] 4 years ago. We have used them in each disease center to make sure ...

Self-organizing multicellular systems derived from mouse embryonic stem (mES) cells called gastruloids, which previously have been shown to mimic critical events of mammalian gastrulation, have been ...

Mechanisms of heart-valve disease often mimic processes observed in embryonic and early childhood development, including activation of valvular interstitial cell (VIC) phenotypes and remodeling of ...

The interplay between host immunity, the microbiota, and cancer is a rapidly evolving area of immuno-oncology. An increasing body of evidence highlights the ...