Microbiota are recognized as key regulators of the gut-brain axis, but whether brain neurons can directly sense bacterial components, and conversely, if bacteria are involved in modulating ...

New research published in the journal Science reports the discovery of a unique pathway by which bacteria in the gut can directly communicate with neurons in the brain responsible for regulating ...

Phagocytosed microorganisms release ligands recognized by NOD proteins and peptides that associate with MHC II molecules. Recognition of intracellular ligands by NOD proteins and extracellular ligands ...

A gene which confers susceptibility to the gut disorder Crohn's disease has been pinpointed by research teams in the US and Europe 1, 2 The defective gene may make the intestine attack its native ...

Co-first author Mahitha Shree Anandachar (center), a Ph.D. student in Biomedical Sciences at UC San Diego, with student research assistant Jasmin Salem (left) and Pradipta Ghosh, M.D. (right). The ...

Imhotex Ltd. has disclosed desmuramylpeptide (DMP) analogues of muramyl dipeptide (MDP) acting as nucleotide-binding oligomerization domain-containing protein 2 (NOD2) activators reported to be useful ...

Your gut harbors trillions of microbes which live in precarious harmony with your immune system. When that harmony is upset, the results can be excruciating—especially for those with Crohn’s disease, ...

Immunologists have identified an important intermediate step in innate immune defense. If bacteria enter the body, it often takes just a few minutes for the innate immune system to recognise them as ...

New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease. Mount Sinai researchers have identified genetic and cellular mechanisms ...