DMBT1 is a multifunctional secreted protein that plays a pivotal role in the body’s first line of defence across mucosal surfaces. Characterised by its scavenger receptor cysteine-rich (SRCR) domains, ...

Intraepithelial lymphocytes (IELs) are a heterogeneous group of immune cells that reside within the epithelial layer of the intestine, forming a critical component of mucosal immunity. These cells ...

A new study has found that a substance produced by gut microbes activates mucosal immunity, the first line of defense against infection, thereby increasing vaccine effectiveness. This research provide ...

In a multi-institutional study published today in Nature Nanotechnology, researchers from The University of Texas MD Anderson ...

Vaccines save millions of lives every year, but there is still an urgent need for more efficient vaccines. Strategies to combat serious outbreaks of viral infections are particularly important. Such ...

Early impairment of mucosal immunoglobulin A (IgA)-related immunity was associated with the later development of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients; decreased ...

A team of scientists, led by Duke-NUS Medical School, has discovered a potential intranasal vaccine candidate that provides improved, longer-lasting immunity against SARS-CoV-2 viruses compared to ...

Whooping cough, also known as pertussis, has re-emerged worldwide and continues to be a major health concern. Caused by the bacterium Bordetella pertussis, this contagious respiratory infection can ...

A new study led by University of Toronto researchers has shown that immune cells in the gut follow an atypical pathway to produce antibodies that provide long-term protection against viruses. The ...

Vaccine was safe and well-tolerated and led to a significant increase in norovirus-specific antibodies in serum and breast milkNorovirus-specific ...