We can all recognise that feeling of muscle fatigue after taking a brisk walk, cycling, running or playing football. Our ability to engage in physical activity for long periods of time is thanks to ...

This Collection supports and amplifies research related to SDG 3 and SDG 9. Mitochondrial dysfunction has been identified as a hallmark of aging, playing a central role in age-associated decline ...

Longevity science has spent decades chasing single molecules that might slow aging, but most candidates have delivered modest, inconsistent results. A new line of research is now pointing to a ...

Unlike our organs, cell organelles such as mitochondria are not fixed in place, but when, where, how, and why organelles move remain unclear. Research published in the Biophysical Journal shows that ...

Fifty years since its discovery, scientists have finally worked out how a molecular machine found in mitochondria, the 'powerhouses' of our cells, allows us to make the fuel we need from sugars, a ...

Mitochondrial respiratory complexes (Complexes I–V) and their assembly into respiratory supercomplexes (SCs) are fundamental to liver bioenergetics, redox homeostasis, and metabolic adaptability.