The tiny little powerhouses of our cells, the mitochondria, are unique among organelles because they carry their own tiny ...

Doubly uniparental inheritance (DUI) of mitochondrial DNA (mtDNA) represents a rare and intriguing deviation from the standard model of strictly maternal inheritance. In bivalves, DUI manifests as the ...

In most eukaryotes, the inheritance of mitochondrion and its DNA (mtDNA) is strictly maternal, despite the fact that a spermatozoon can inject up to 100 functional mitochondria into the oocyte during ...

A new study from deCODE genetics uses pedigrees and sequence data from 64,806 Icelanders to shed light on the rate and nature of mutations in mitochondrial DNA (mtDNA) and the peculiar dynamics of its ...

Management of mitochondrial-related heart disease relies on multidisciplinary care and symptom control, as targeted gene-editing therapies are limited.

Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...

Integrative and Comparative Biology, Vol. 59, No. 4 (October 2019), pp. 983-993 (11 pages) Despite wide-ranging implications of selfish mitochondrial DNA (mtDNA) elements for human disease and topics ...

According to a recent AHA Scientific Statement, despite ongoing limitations, recent advances in genomic sequencing ...

A study published in the latest issue of Science reveals a cellular mechanism involved in the inheritance of genetic mutations. The study also points to a potential treatment that could reduce the ...