A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...
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Scientists watch drug molecules hit cell receptors in real time
Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...
Researchers at the University of North Carolina (UNC) at Chapel Hill School of Medicine have revealed the detailed structure of the bitter taste receptor, a protein called TAS2R14, and have shown ...
New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...
Histamine is widely known for its role in allergic reactions but also functions as a key neurotransmitter in the brain, where ...
“Tasting Upside-Down - An Unusual Sensing Mechanism was Found in Human Bitter Sensing” A new study revealed that some bitter molecules target their sensor through binding simultaneously at two ...
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