Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...

As high-throughput techniques accelerate mapping of epigenetic marks, researchers are racing to find the biological meaning of these marks. Thanks to the Human Genome Project, researchers worldwide ...

Much like mapping the human genome laid the foundations for understanding the genetic basis of human health, new maps of the human epigenome may further unravel the complex links between DNA and ...

A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, ...

Background: Next-generation sequencing (NGS) is opening a new era for understanding how the human genome is altered in the process of cancer development. We sought to establish an epigenome map based ...

Scientists at Fred Hutchinson Cancer Research Center have published a new method that allows investigators to map chromatin — the DNA modifications, packaging proteins and molecular factors that work ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

Since the advent of the Human Genome Project, scientists have expanded efforts to map complete biological datasets that encompass entire molecular families, such as DNA, RNA, proteins, and metabolites ...

Biopsy for custom-made treatment: mRNA expression level of cancer-critical genes from gastric/colorectal cancer tissues obtained by endoscopic biopsy. Background: Next-generation sequencing (NGS) is ...