Recently discovered electrophilic probes open the door to activity-based protein profiling (ABPP) studies of a broader range of proteins. It can be extremely challenging to study enzymes. Without any ...

In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple ...

Recent studies show that redox-active small molecules are selectively cytotoxic to chronic lymphocytic leukemia (CLL). Although elevated levels of reactive oxygen species in CLL cells have been ...

New electrophilic reagents for activity-based protein profiling (ABPP) can discriminate between nucleophilic amino acids, such as cysteine, that are in different protein microenvironments. These ...

Radiochemists can now expand their toolbox of molecular probes for positron emission tomography (PET), thanks to a new electrophilic fluorinating reagent. The palladium-based compound is made with 18 ...

Organic chemists love their functional groups and perhaps the most hotly pursued of these amours is the amine. Arylamines, for example, are often important components of pharmaceuticals or other ...