CAR T-cell therapy has transformed the treatment of hematologic malignancies, yet many patients do not achieve lasting ...

A first-in-human trial has shown that CAR-T cells engineered to have a stem cell–like memory phenotype can induce complete remissions in blood cancer patients without the usual chemotherapy ...

Examine how large-scale screening of AI-designed binders informs CAR T-cell engineering and functional validation.

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack ...