To clarify whether CFTR is a molecular target of intestinal fluid secretion caused by the anthraquinone compounds from laxative herbal plants. In the present study, we determined the potentiating ...

The regulatory (R) region of the cystic fibrosis transmembrane conductance regulator (CFTR) is intrinsically disordered and must be phosphorylated at multiple sites for full CFTR channel activity, ...

Residual CFTR function in cystic fibrosis was associated with better glucose tolerance and insulin secretion, with CFTR ...

A number of experimental techniques that involve measurements in engineered CF cell lines (available through the Center’s Gene Expression Core) and tissues of CF animal models (available through the ...

Please provide your email address to receive an email when new articles are posted on . Patients from minority racial and ethnic groups with cystic fibrosis are less likely to be eligible for cystic ...

Scientific experiments examining what happens to the faulty channel protein that causes cystic fibrosis during inflammation have yielded unexpected and exciting results. The study, conducted by Sara ...

Protein folding diseases, from Alzheimer's to Gaucher's, may one day be treated by a unique class of protein corrector molecules that are already helping manage cystic fibrosis. Protein misfolding is ...

Fluorescence microscope image of cells in the lung’s blood vessels. The study has shown for the first time that these cells possess a CFTR chloride channel (green), and that lung inflammation-induced ...

Cystic Fibrosis, a fatal lung disease striking one in 2,500 people, may be caused by a failure of the cilia to maintain the level of water associated with the mucus in the lungs, causing the natural ...

Better understand cystic fibrosis / Study in "Journal of Medical Genetics” Cystic fibrosis is the most frequent severe inherited disorder worldwide. Every year, hundreds of families are confronted ...

Protein misfolding is a likely culprit in many degenerative disorders. Cystic fibrosis, for instance, is caused by mutations in the CFTR gene that prevent the eponymous protein from assuming its ...

Mini-guts grown in the lab using cystic fibrosis patients' cells can help pinpoint those who are most likely to benefit from new drugs, according to a new study. The findings pave the way to ...