This is a preview. Log in through your library . Abstract Cleavage and release of membrane protein ectodomains, a regulated process that affects many cell surface proteins, remains largely ...

Cerebrospinal fluid (CSF) is a clear and watery liquid that flows in and around the brain and spinal cord. Its functions include protecting parts of the nervous system, delivering nutrients and ...

Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study. For several decades, researchers studying Alzheimer's disease have been working to understand ...

An estimated 50 million people worldwide have dementia, with Alzheimer's disease—accounting for more than 70%—being the representative neurodegenerative brain disorder. A Korean research team has, for ...

Aη, or A-eta, made an initial splash when scientists reported that these fragments of amyloid precursor protein—products of a heretofore unknown cleavage—dampen neural activity. But how? The story ...

In a recent study published in the journal PLOS Biology, researchers used mouse models to demonstrate that neurons were not the only source of abnormal amyloid β proteins contributing to the pathology ...

Prof. Liu Cong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, along with collaborators, has revealed the high-resolution structures of amyloid fibrils directly ...

Transthyretin amyloidosis (ATTR) is a rare, progressive and highly aggressive degenerative disease. It is caused by the ...

With people now being treated with amyloid immunotherapy in the clinic, reducing the risk of ARIA has taken on a new sense of urgency. This inflammatory side effect occurs in people who have amyloid ...